Pathogenic analysis of Campylobacter jejuni in Fengtai District
10.3969/j.issn.1006-2483.2026.04.015
- VernacularTitle:北京丰台区空肠弯曲菌病原学分析
- Author:
Zhaoe WANG
1
;
Mei QU
2
;
Huiru FENG
1
;
Zhuo MA
1
;
Zhimin ZHANG
1
Author Information
1. Beijing Fengtai District Center for Disease Control and Prevention, Beijing 100070, China
2. Beijing Center for Disease Control and Prevention, Beijing 100031, China
- Publication Type:Journal Article
- Keywords:
Campylobacter jejun;
Serotyping;
Whole genome sequencing
- From:
Journal of Public Health and Preventive Medicine
2026;37(4):71-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the drug resistance phenotype/genotype and virulence gene carrying status, serotype, and sequence typing (ST) of Campylobacter jejuni in Fengtai District in 2024. Methods The drug resistance phenotype was detected by agar dilution method, and serotyping was performed by real-time fluorescence quantitative polymerase chain reaction (PCR). The whole genome sequencing was used to analyze drug resistance genes, virulence genes, and other characteristics. Results Among the 35 Campylobacter jejuni strains analyzed, the antibiotics with the highest resistance rates were nalidixic acid and ciprofloxacin (both 82.86%), followed by tetracycline (74.89%). All strains exhibited a 100.00% sensitivity rate to erythromycin. The multiple drug resistance rate was 77.14%. The predominant drug resistance genes were gyrA-T86I (94.29%) and tetO (74.29%). The most common serotype was HS:2, accounting for 25 strains. A total of 132 virulence genes were detected. There were 12 clonal complexes (CC) and 24 ST types. Conclusion The drug resistance situation of Campylobacter jejuni in Fengtai District is relatively severe, and the drug resistance phenotype is related to specific genetic mutations to some extent. The serotypes are diverse, the virulence genes are complex, and the pathogenic potential is significant, posing a notable risk for inducing Guillain-Barré syndrome (GBS). The high number of ST types indicates substantial genetic diversity.
