Pathogenesis, disease spectrum, and treatment advances of ocular neuroinflammation
10.3980/j.issn.1672-5123.2026.8.15
- VernacularTitle:眼部神经炎症发病机制疾病谱系及治疗进展
- Author:
Xiaoyu WANG
1
;
Yi SHAO
1
Author Information
1. Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi, China
- Publication Type:Journal Article
- Keywords:
neuroinflammation;
eye diseases;
blood-retinal barrier;
targeted therapy;
biomarkers
- From:
International Eye Science
2026;26(8):1394-1399
- CountryChina
- Language:Chinese
-
Abstract:
Ocular neuroinflammation has moved beyond being regarded as a mere accompanying phenomenon and has emerged as a central paradigm for understanding the onset, progression, and outcome of a variety of blinding eye diseases. It serves as a common pathological thread that traverses etiologically diverse conditions, closely linking acute injury with chronic degeneration, autoimmunity with psychological stress, and vascular events with metabolic dysregulation. This review aims to construct a broader framework that not only deepens mechanistic understanding of neuroinflammation in classic ocular disorders, but also extends the perspective to a wider disease spectrum. Furthermore, cutting-edge advances from basic research to clinical translation were systematically summarized, thereby providing a panoramic view of the current landscape and future directions of ocular neuroinflammation research.
