Research progress of high-altitude retinopathy
10.3980/j.issn.1672-5123.2026.8.12
- VernacularTitle:高海拔视网膜病变研究进展
- Author:
Ziyang LUO
1
;
Haorui ZHANG
1
;
Guorui DOU
1
;
Liang WANG
1
Author Information
1. Department of Ophthalmology, Xijing Hospital, Air Force Military Medical University;Eye Institute of Chinese PLA, Xi'an 710032, Shaanxi Province, China; School of Basic Medicine
- Publication Type:Journal Article
- Keywords:
high-altitude retinopathy;
pathogenesis;
anti-vascular endothelial growth factor;
oxidative stress;
intervention strategies
- From:
International Eye Science
2026;26(8):1376-1381
- CountryChina
- Language:Chinese
-
Abstract:
High-altitude retinopathy(HAR)is a retinal vascular disorder induced by exposure to high-altitude environments. With the increasing popularity of high-altitude travel, mountaineering, and special occupational activities, worldwide, the incidence of HAR has risen, particularly among individuals with rapid or short-term exposure to elevated altitudes. Most cases of HAR are self-limiting and gradually resolve with descent to lower altitudes. However, severe cases may result in permanent visual function impairment if not recognized and managed promptly. This review systematically summarizes the epidemiology, diagnostic progress, pathogenesis, and prevention and treatment strategies of HAR, with particular emphasis on hypoxia-associated molecular pathways involved in retinal damage, and evaluates current evidence for clinical interventions. Deepened understanding of its pathological mechanisms and clinical management strategies facilitates early identification, targeted intervention, and ocular health protection for populations exposed to high altitudes.
