Advances in extracellular vesicles for the diagnosis and treatment of corneal and ocular surface diseases
10.3980/j.issn.1672-5123.2026.8.10
- VernacularTitle:细胞外囊泡在角膜及眼表疾病诊断与治疗中的研究进展
- Author:
Zhihao ZHANG
1
;
Jiahao WANG
1
;
Qihang DIAO
1
;
Jingjing ZHAO
1
;
Mengjun FU
1
Author Information
1. Weifang Eye Hospital;Zhengda Guangming Ophthalmology Group, Weifang 261000, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
extracellular vesicles;
corneal regeneration;
dry eye disease;
drug delivery;
immune regulation
- From:
International Eye Science
2026;26(8):1365-1370
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles(EVs)are nanoscale membrane vesicles released by cells that carry bioactive molecules such as proteins and nucleic acids. They play a key role in intercellular communication. In recent years, they have shown significant potential in the diagnosis and treatment of corneal and ocular surface diseases. As diagnostic biomarkers, EVs derived from tears or other sources can reflect disease-specific characteristics, providing a basis for the early disease detection. In terms of therapy, mesenchymal stem cells(MSCs)-derived EVs deliver miRNAs to modulate inflammatory pathways, promote corneal epithelial repair, and inhibit fibrosis. Furthermore, as natural drug vehicles, EVs enable precise delivery of therapeutic agents and promote corneal wound healing. This review systematically summarizes the recent research advances in the application of EVs in the field.
