Treatment of Ankylosing Spondylitis Based on the Dynamic Pathogenesis of "Heat Bi （痹）-Marrow Deficiency-Bone Damage"
10.13288/j.11-2166/r.2026.14.008
- VernacularTitle:基于“热痹-髓亏-骨损”动态病机论治强直性脊柱炎
- Author:
Tiantian SUN
1
;
Hongxiao LIU
1
Author Information
1. Guang 'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing，100053
- Publication Type:Journal Article
- Keywords:
ankylosing spondylitis;
heat bi （痹）;
marrow deficiency;
bone damage
- From:
Journal of Traditional Chinese Medicine
2026;67(14):1509-1513
- CountryChina
- Language:Chinese
-
Abstract:
Based on the understanding of "kidney storing essence and marrow nourishing bone"， and in combination with the modern pathological characteristics of ankylosing spondylitis （AS）， this paper systematically elucidates the dynamic pathogenesis evolution of "heat bi （inflammatory activity）-marrow deficiency （bone marrow edema）-bone damage （bone structural damage）" in AS. It is proposed that in the heat bi stage， there is kidney deficiency with pathogenic invasion and heat congesting the meridians. In the marrow deficiency stage， heat consumes kidney essence， leading to marrow injury and collateral obstruction. In the bone damage stage， kidney exhaustion and marrow emptiness occur， with phlegm-stasis congealing on bone. Accordingly， a stage-specific treatment strategy for AS is established. In the heat bi stage， treatment focuses on supplementing the kidney and replenishing essence， clearing heat and unblocking collaterals. In the marrow deficiency stage， the main approach is to supplement the kidney and benefit marrow， unblock collaterals and reduce edema. In the bone damage stage， it is suggested to supplement the kidney and replenish essence， benefit marrow and strengthen bone， resolve phlegm and expel stasis.
