Application of liquid biopsy in early screening and diagnosis of pancreatic cancer
- VernacularTitle:液体活检在胰腺癌早期筛查诊断中的应用
- Author:
Junyu CHEN
1
;
Pan ZHAO
1
;
Xiao LI
1
;
Zhengcai LIU
1
;
Shuqiang YUE
1
Author Information
- Publication Type:Review
- Keywords: Pancreatic Neoplasms; Liquid Biopsy; Neoplastic Cells， Circulating; Circulating Tumor DNA; Extracellular Vesicles
- From: Journal of Clinical Hepatology 2026;42(6):1481-1488
- CountryChina
- Language:Chinese
- Abstract: Pancreatic cancer is characterized by occult clinical manifestations and high malignancy， and conventional imaging examinations and carbohydrate antigen 19-9 lack sufficient sensitivity and specificity for detecting early-stage pancreatic cancer lesions. Difficulty in early diagnosis severely restricts the long-term survival of pancreatic cancer patients. Liquid biopsy targets the biomarkers in body fluid samples， including circulating tumor cells， circulating tumor DNA， circulating tumor microRNA， and extracellular vesicles， showing the advantages of noninvasiveness and continuous monitoring. This review systematically summarizes the latest advances in liquid biopsy for the early screening and diagnosis， recurrence prediction， and prognostic assessment of pancreatic cancer， aiming to provide new insights and references for precision screening of high-risk populations and the clinical translation of liquid biopsy.
