Evaluation methods and strategies for the synergistic effect of drug combinations in pancreatic diseases
- VernacularTitle:胰腺疾病治疗药物联合应用协同作用的评价方法与策略
- Author:
Shuyuan LIU
1
;
Shurong MA
1
;
Dong SHANG
1
Author Information
- Publication Type:Review
- Keywords: Pancreatic Diseases; Drug Synergism; Drug Evaluation
- From: Journal of Clinical Hepatology 2026;42(6):1475-1480
- CountryChina
- Language:Chinese
- Abstract: Pancreatic diseases are characterized by difficulties in diagnosis and treatment， as well as complex pathogenic mechanisms. Combined drug therapy can enhance therapeutic efficacy， overcome drug resistance， and reduce adverse effects through synergistic interactions and has thus emerged as an important strategy for improving the treatment of pancreatic diseases. This article systematically reviews the commonly used methods for evaluating the synergistic effect of drug combinations， including isobologram analysis， the Chou-Talalay method， Jin’s formula， and the weighted sum method， as well as the theoretical basis， applicability， and limitations of each method， and this article also summarizes the recent advances in their application in pancreatic diseases including pancreatic cancer and acute pancreatitis. By comparing the characteristics of different methods in terms of measurement accuracy and experimental dependence， this article further proposes a framework for evaluating the effect of multi-drug combinations tailored to pancreatic diseases， thereby providing a basis for the screening and optimization of drug combination regimens， as well as new perspectives for the future development of synergistic evaluation models and combined therapeutic strategies.
