Role and mechanism of semaphorins in liver diseases
- VernacularTitle:信号素在肝脏疾病中的作用及其机制
- Author:
Manwula MUBARESI
1
;
Xuan DING
1
;
Yidan LUO
1
;
Qingshuai LIANG
1
;
Xu ZHOU
1
;
Yuwu LIU
1
Author Information
- Publication Type:Review
- Keywords: Semaphorins; Liver Disease; Plexin; Neuropilin
- From: Journal of Clinical Hepatology 2026;42(6):1454-1461
- CountryChina
- Language:Chinese
- Abstract: The liver is a vital metabolic organ sustaining human life activities， and its dysfunction is closely associated with various liver diseases. In recent years， an increasing number of studies have shown that semaphorins （SEMA） play a significant role in pathological processes such as immune inflammatory response， tumor progression， and fibrosis in liver diseases by interacting with their receptors plexins and neuropilins. This article reviews the expression， functions， and molecular mechanisms of different SEMA in viral hepatitis， hepatocellular carcinoma， liver fibrosis， nonalcoholic fatty liver disease， and hepatic ischemia-reperfusion injury， and it also explores the potential application value of SEMA in the diagnosis and treatment of liver diseases， in order to provide new ideas for precise diagnosis and targeted treatment of liver diseases.
