Role of ferroptosis in the progression and treatment of liver fibrosis

Jungang LI; Fengfan LI; Zhenni LIU; Weichu ZENG; Weilin ZHANG; Peiting LIU; Bingchu LI; Xing LYU; Ruohong CHEN; Zhiyang CHEN; Min HU

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Role of ferroptosis in the progression and treatment of liver fibrosis

VernacularTitle:铁死亡在肝纤维化进展和治疗中的作用
Author: Jungang LI ¹ ; Fengfan LI ¹ ; Zhenni LIU ¹ ; Weichu ZENG ¹ ; Weilin ZHANG ¹ ; Peiting LIU ¹ ; Bingchu LI ¹ ; Xing LYU ¹ ; Ruohong CHEN ¹ ; Zhiyang CHEN ¹ ; Min HU ¹
Author Information

1. Department of Laboratory Medicine， The Second Xiangya Hospital of Central South University； Hunan Provincial Center for Clinical Molecular Diagnostics； Hunan Engineering Research Center for Molecular Diagnostic Technology； Hunan Clinical Research Center for Molecular Diagnosis of Infectious Diseases， Changsha 410011， China
Publication Type:Review
Keywords: Hepatic Fibrosis; Ferroptosis; Therapeutics
From: Journal of Clinical Hepatology 2026;42(6):1426-1432
CountryChina
Language:Chinese
Abstract: Liver fibrosis is a critical pathological process in the progression of chronic liver diseases and is mainly driven by the activation of hepatic stellate cells， and it is characterized by excessive deposition of extracellular matrix. Programmed cell death is widely observed in liver fibrosis and plays diverse roles in different types of cells. It is not only a mechanism for maintaining cellular homeostasis through metabolism， but it can also regulate the development and progression of diseases. Ferroptosis has recently emerged as a research focus due to its close association with lipid metabolism. This article systematically reviews the related concepts of lipid metabolism， ferroptosis， and liver fibrosis， analyzes the bridging role and dual regulatory function of ferroptosis in lipid metabolism and liver fibrosis， and further highlights the clinical application value of targeting ferroptosis in hepatic stellate cells for the treatment of liver fibrosis， in order to provide new perspectives for the mechanistic studies on liver fibrosis and the optimization of related clinical intervention strategies.