Role of naringenin in the prevention and treatment of autoimmune hepatitis and its molecular mechanism

Changwen LIN; Qiuyi REN; Mengjie ZHENG; Huan YAN; Jia LI; Jiaxin FENG; Haiying LIN; Faming SHU; Xiaoling ZHOU; Dewen MAO; Fuli LONG

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Role of naringenin in the prevention and treatment of autoimmune hepatitis and its molecular mechanism

VernacularTitle:柚皮素对自身免疫性肝炎的防治作用及分子机制
Author: Changwen LIN ¹ ; Qiuyi REN ² ; Mengjie ZHENG ¹ ; Huan YAN ¹ ; Jia LI ¹ ; Jiaxin FENG ¹ ; Haiying LIN ³ ; Faming SHU ³ ; Xiaoling ZHOU ³ ; Dewen MAO ³ ; Fuli LONG ³
Author Information

1. The First Clinical Medical College of Guangxi University of Chinese Medicine， Nanning 530023， China
2. Department of Neurology， The First Affiliated Hospital of Dalian Medical University， Dalian， Liaoning 116011， China
3. Department of Hepatology， The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， China
Publication Type:Review
Keywords: Naringenin; Hepatitis， Autoimmune; Immunomodulation; Signal Transduction
From: Journal of Clinical Hepatology 2026;42(6):1419-1425
CountryChina
Language:Chinese
Abstract: Autoimmune hepatitis （AIH） is a chronic inflammatory liver disease mediated by T lymphocytes， and it can progress to liver cirrhosis or even liver failure without timely intervention. As a natural flavonoid compound， naringenin （NAR） shows a potential value in the prevention and treatment of AIH through multiple mechanisms such as remodeling immune homeostasis， targeted inhibition of inflammatory pathways， antioxidation， regulating hepatocyte metabolism and apoptosis， improving mitochondrial function， and regulating intestinal flora. However， the clinical translation and application of NAR is limited by issues such as low bioavailability and insufficient efficiency of liver-targeted delivery. This article systematically reviews the mechanism of action of NAR in the prevention and treatment of AIH， explores the potential signaling pathways involved in this process， and analyzes existing challenges in its translation and application and future research directions， so as to provide a reference for further research on NAR and its application in the prevention and treatment of AIH.