Regulatory mechanism of telomere in metabolic associated fatty liver disease and related targeted therapies
- VernacularTitle:端粒对代谢相关脂肪性肝病的调控作用机制及相关靶向治疗
- Author:
Yiming ZHAO
1
;
Xiaomei WU
1
;
Jing HUANG
2
;
Qi ZHAO
2
;
Mei YANG
3
Author Information
- Publication Type:Review
- Keywords: Metabolic Associated Fatty Liver Disease; Telomere Shortening; Nucleotide Metabolism; Oxidative Stress; Epigenomics
- From: Journal of Clinical Hepatology 2026;42(6):1411-1418
- CountryChina
- Language:Chinese
- Abstract: Metabolic associated fatty liver disease （MAFLD） is the most prevalent chronic liver disease worldwide， and its progression is closely associated with the development of liver fibrosis， liver cirrhosis， and even hepatocellular carcinoma. However， there is still a lack of effective therapies for MAFLD in clinical practice. Telomere is the protective structure at the end of chromosomes， and telomere shortening and functional impairment have been identified as one of the key factors regulating the pathological progression of MAFLD. This article systematically reviews the core mechanism of action of telomere regulation in MAFLD， including its molecular functions in nucleotide metabolism， oxidative stress， and epigenetic regulation， as well as its pathological effect in hepatocytes and hepatic stellate cells. In addition， this article explores the clinical prospects of telomeres as biomarkers and therapeutic targets for MAFLD， in order to provide a theoretical reference for improving the precise diagnosis and treatment system of MAFLD.
