Association between the gut microbiota-Toll-like receptor axis and metabolic associated fatty liver disease
- VernacularTitle:肠道菌群-Toll样受体轴与代谢相关脂肪性肝病的关系
- Author:
Yuanyuan SUN
1
;
Cunzheng ZHANG
1
;
Jingyuan XU
1
;
Chunxiao ZHOU
1
Author Information
- Publication Type:Review
- Keywords: Metabolic Associated Fatty Liver Disease; Gastrointestinal Microbiome; Toll-Like Receptor
- From: Journal of Clinical Hepatology 2026;42(6):1404-1410
- CountryChina
- Language:Chinese
- Abstract: The pathogenesis of metabolic associated fatty liver disease （MAFLD） is closely associated with gut microbiota dysbiosis. Dysbiosis can lead to translocation of bacterial derivatives （such as lipopolysaccharide）， which drives hepatic inflammatory response and metabolic imbalance by activating Toll-like receptors （TLR） and their downstream signaling pathways. This article systematically reviews the mechanism of action of the gut microbiota-TLR axis in MAFLD， and elaborates on the function of the key receptors such as TLR2 and TLR4 and the lesser-studied members （TLR5， TLR7， and TLR9）. This article also summarizes the downstream signaling events after TLR activation， including the canonical NF-κB and MAPK pathways， as well as the role of the JAK-STAT and PI3K-Akt pathways in the pathological mechanism of MAFLD. Finally， this article reviews the potential intervention strategies for MAFLD by targeting gut microbiota and regulating the gut microbiota-TLR signaling axis， in order to provide new ideas for clinical prevention and treatment.
