Association between endoplasmic reticulum stress and ferroptosis in metabolic associated fatty liver disease
- VernacularTitle:代谢相关脂肪性肝病中内质网应激与铁死亡的关系
- Author:
Liang SHI
1
;
Zhanjie CHANG
2
;
Chunxiao YAN
1
;
Junzhe JIAO
2
;
Ruijuan YAN
2
;
Shuguang YAN
3
;
Jingtao LI
2
;
Haibo ZHANG
3
Author Information
- Publication Type:Review
- Keywords: Metabolic Dysfunction-Associated Fatty Liver Disease; Endoplasmic Reticulum Stress; Ferroptosis
- From: Journal of Clinical Hepatology 2026;42(6):1398-1403
- CountryChina
- Language:Chinese
- Abstract: Metabolic associated fatty liver disease （MAFLD） is a highly prevalent chronic liver disease worldwide， and the mechanism underlying its progression to metabolic associated steatohepatitis and liver fibrosis remain unclear. Endoplasmic reticulum stress （ERS） and ferroptosis （Fer） are deeply involved in the pathological evolution of MAFLD. This article systematically reviews the core regulatory mechanisms of ERS and its role in regulating lipid metabolism， inflammation response， and cell apoptosis in MAFLD. It also analyzes the core mechanism of Fer and discusses the predisposing factors for Fer in the pathological microenvironment of MAFLD， as well as the role of Fer in exacerbating hepatocyte death and activating the progression of liver fibrosis. This article proposes that the crosstalk between ERS and Fer is a key driver for the progression of MAFLD， which provides new references and ideas for the clinical intervention of MAFLD.
