Role of O-linked β-N-acetylglucosamine modification in metabolic associated fatty liver disease
- VernacularTitle:O-连接β-N-乙酰葡萄糖胺糖基化修饰在代谢相关脂肪性肝病中的作用
- Author:
Sutong LIU
1
;
Lihui ZHANG
1
;
Qing ZHAO
1
;
Weichen MA
1
;
Wanyi ZHU
1
;
Minghao LIU
1
;
Wenxia ZHAO
1
Author Information
- Publication Type:Review
- Keywords: Metabolic Associated Fatty Liver Disease; O-linked β-N-Acetylglucosamine; Protein Processing， Post-Translational
- From: Journal of Clinical Hepatology 2026;42(6):1391-1397
- CountryChina
- Language:Chinese
- Abstract: Metabolic associated fatty liver disease （MAFLD） is a chronic liver disease with a rapidly increasing incidence rate worldwide， and its complex pathogenesis is closely associated with O-linked β-N-acetylglucosamine （O-GlcNAc） modification. As a dynamic and reversible post-translational modification of proteins， O-GlcNAc modification is mainly regulated by O-GlcNAc transferase and O-GlcNAcase. O-GlcNAc modification can drive hepatic steatosis， exacerbate insulin resistance， and impair mitochondrial function， thereby leading to the aggravation of metabolic disorders， promoting inflammation response， and driving the progression of MAFLD to metabolic associated steatohepatitis and hepatic fibrosis. This article systematically reviews the latest research advances in the role of O-GlcNAc modification in the development and progression of MAFLD， in order to provide theoretical support and research direction for a deeper understanding of the pathological mechanism of MAFLD and the development of effective therapeutic strategies.
