Epidemiology， mechanism， prevention， and treatment of reduced bone mineral density associated with liver cirrhosis
- VernacularTitle:肝硬化相关骨密度降低的流行病学、机制与防治
- Author:
Lingyun WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Liver Cirrhosis; Bone Density; Osteoporosis
- From: Journal of Clinical Hepatology 2026;42(6):1253-1259
- CountryChina
- Language:Chinese
- Abstract: Patients with liver cirrhosis often experience a reduction in bone mineral density （BMD） or even osteoporosis （OP） due to long-term chronic liver dysfunction and systemic metabolic disorders， and this condition has become one of the major complications affecting their quality of life and long-term prognosis. This article systematically reviews the epidemiological characteristics of reduced BMD associated with liver cirrhosis， summarizes the incidence of reduced BMD in liver cirrhosis patients with different etiologies， and analyzes its association with disease severity. This article further discusses the main pathophysiological mechanisms of reduced BMD induced by liver cirrhosis （including calcium/phosphorus metabolism disorders， sex hormone imbalance， chronic inflammatory response， and bone metabolism dysregulation）， reviews the clinical manifestations， fracture risk， and adverse outcomes associated with reduced BMD， and summarizes current prevention and treatment strategies for cirrhosis-related OP. This review aims to integrate recent research advances in this field and to provide a reference for future mechanistic studies and standardized clinical management.
