Research progress on the association between lung microbiome and chronic lung allograft dysfunction
10.12464/j.issn.1674-7445.2026032
- VernacularTitle:肺部微生物组与慢性移植肺功能障碍关联的研究进展
- Author:
Tianle WANG
1
;
Wuji LI
1
;
Chunxiao HU
2
;
Mingfeng ZHENG
1
Author Information
1. Department of Thoracic Surgery, Wuxi Medical Center, Nanjing Medical University, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi 214023, China.
2. null.
- Publication Type:ReviewArticle
- Keywords:
Lung transplantation;
Chronic lung allograft dysfunction;
Microbiome;
Bacterial burden;
Bronchiolitis obliterans syndrome;
Restrictive allograft syndrome;
Epithelial-mesenchymal transition
- From:
Organ Transplantation
2026;17(4):688-694
- CountryChina
- Language:Chinese
-
Abstract:
Chronic lung allograft dysfunction (CLAD) is a common complication after lung transplantation, which severely impairs the long-term survival of patients. At present, effective therapeutic approaches remain lacking. Dysregulation of the lung microbiome acts as a pathogenic factor for a variety of pulmonary diseases. Accumulating studies have demonstrated that the compositional characteristics of the lung microbiome after lung transplantation are closely associated with CLAD. Therefore, this article reviews the definition of CLAD, characteristics of the lung microbiome, the influence of the lung microbiome on the occurrence and progression of CLAD, the potential mechanisms underlying the lung microbiome in the pathogenesis of CLAD, and microbiome-based intervention strategies for CLAD. It aims to provide novel insights for the prevention and treatment of CLAD following lung transplantation and further improve the prognosis of lung transplant recipients.
