Challenges and management strategies of obesity in the clinical practive of liver transplantation
10.12464/j.issn.1674-7445.2026009
- VernacularTitle:肥胖在肝移植临床实践中的挑战与管理策略
- Author:
Tianfei GAO
1
;
Xiaoqin LIU
2
;
Kun YANG
1
;
Yi SU
1
;
Zengxi LUO
1
;
Yingpeng ZHAO
1
Author Information
1. Department of Hepatobiliary Surgery, Ganmei Hospital Affiliated to Kunming Medical University, Kunming First People's Hospital, Kunming 650224, China.
2. null.
- Publication Type:ReviewArticle
- Keywords:
Obesity;
Liver transplantation;
Metabolic dysfunction-associated steatotic liver disease;
Transplant prognosis;
Body mass index;
Hepatic steatosis;
Sarcopenic obesity;
Cardiovascular risk
- From:
Organ Transplantation
2026;17(4):659-665
- CountryChina
- Language:Chinese
-
Abstract:
Obesity has become one of the important factors affecting the entire management process of liver transplantation. Its impact is not only reflected in the increased risk of liver steatosis and ischemia-reperfusion injury in the donor, but also involves the increased technical difficulty during the perioperative period for the recipient, the increase in postoperative metabolic complications and poorer long-term prognosis. This article, based on recent relevant studies, reviews aspects such as the utilization of obese donors, the characteristics of adult and pediatric recipients, pre-transplant risk assessment and weight loss intervention, and post-transplant weight and metabolic management. Current evidence suggests that simply judging transplantation risks based on body mass index has limitations. Analysis of body composition, assessment of cardiovascular function and identification of sarcopenic obesity are more clinically valuable. For obese liver transplant recipients, in a multidisciplinary collaboration framework, emphasis should be placed on individualized screening, perioperative optimization and long-term follow-up management to improve the outcomes of the graft and the recipient.
