Research progress on cell-based immune tolerance induction strategies after pediatric liver transplantation
10.12464/j.issn.1674-7445.2026003
- VernacularTitle:儿童肝移植术后基于细胞的免疫耐受诱导策略的研究进展
- Author:
Jiangning WANG
1
;
Kang HE
1
Author Information
1. Department of Liver Surgery, Affiliated Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
- Publication Type:ReviewArticle
- Keywords:
Pediatric liver transplantation;
Immune tolerance;
Cell therapy;
Regulatory T cell;
Regulatory dendritic cell;
Mesenchymal stem cell;
Hematopoietic stem cell;
Hepatic stellate cell
- From:
Organ Transplantation
2026;17(4):652-658
- CountryChina
- Language:Chinese
-
Abstract:
How to enable children who receive liver transplantation to abandon long-term immunosuppressive drugs while maintaining the function of the transplant organ is the core challenge currently faced in the field of pediatric liver transplantation. Utilizing the developmental plasticity of the child's immune system and actively inducing immune tolerance is the fundamental approach to solving this problem. This article reviews the cell-based immune tolerance induction strategies after pediatric liver transplantation, systematically analyzes the mechanism and research progress of regulatory T cells, regulatory B cells, regulatory dendritic cells, mesenchymal stem cells, hematopoietic stem cells, Vδ1 γδ T cells and hepatic stellate cells, summarizes the core progress and translational challenges in this field, and looks forward to the future of individualized treatment, cell engineering and combined treatment regimens.
