Annual review of global liver transplantation research in 2025
10.12464/j.issn.1674-7445.2026111
- VernacularTitle:2025年全球肝移植研究年度盘点
- Author:
Runmin TANG
1
;
Yongwei HU
1
;
Yong JIANG
1
;
Yang YANG
1
;
Wei LIU
1
Author Information
1. Department of Liver Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangdong Provincial Laboratory of Transplantation Medical Engineering, Guangzhou 510630, China.
- Publication Type:AcademicSummary
- Keywords:
Liver transplantation;
Machine perfusion;
Split liver transplantation;
Xenotransplantation;
Hepatocellular carcinoma;
Minimally invasive technique;
Artificial intelligence;
Bridge downgrade
- From:
Organ Transplantation
2026;17(4):526-540
- CountryChina
- Language:Chinese
-
Abstract:
In 2025, significant breakthroughs were achieved in various aspects of liver transplantation, including xenotransplantation, machine perfusion, minimally invasive surgery, precise immune regulation and artificial intelligence, etc. The successful implementation of gene-modified pig-to-human assisted liver transplantation marked the official entry of xenotransplantation into the clinical transformation stage. The machine perfusion technology completed multiple large-scale clinical validations, significantly improving the transplantation outcomes of marginal donor livers and donor livers from donation after cardiac death, and pushing organ preservation into the era of dynamic functional assessment. Split liver transplantation and living donor liver transplantation continuously optimized in terms of donor-recipient matching, liver utilization and perioperative management. Robotic and laparoscopic technologies further promoted liver transplantation towards the direction of precision and minimally invasive surgery. Hepatocellular carcinoma liver transplantation gradually formed a precise management model centered on immunotherapy, bridge downgrade and recurrence risk prediction. At the same time, artificial intelligence and multi-omics technologies demonstrated significant application value in prognosis prediction, organ allocation and complication risk assessment. This article conducts a systematic review of the important research progress in the field of liver transplantation in 2025 and looks forward to the future development directions and challenges.
