Research progress on pharmacological mechanism of Gastrodiae Rhizoma in the treatment of hypertension
- VernacularTitle:天麻对高血压的药理作用机制研究进展
- Author:
Xiyu HUANG
1
;
Guosheng LUO
1
;
Bin ZHU
1
;
Zhexue HE
1
;
Yongguang HUANG
2
;
Jiafu ZHOU
3
Author Information
1. Graduate School of Guangxi University of Traditional Chinese Medicine，Nanning 530200，China
2. National Research Center for The Inheritance of Jing Ethnic Medicine，Fangchenggang Hospital Affiliated with Guangxi University of Traditional Chinese Medicine，Guangxi Fangchenggang 538021，China
3. Dept. of Traditional Chinese Medicine Research，Division of Pharmacy，Fangchenggang Hospital Affiliated with Guangxi University of Chinese Medicine，Guangxi Fangchenggang 538021，China
- Publication Type:Journal Article
- Keywords:
Gastrodiae Rhizoma;
hypertension;
active ingredients;
herb pairs;
prescriptions
- From:
China Pharmacy
2026;37(13):1791-1796
- CountryChina
- Language:Chinese
-
Abstract:
As a traditional Chinese medicinal herb for pacifying the liver and extinguishing wind， Gastrodiae Rhizoma contains main active ingredients such as gastrodin， gastrodia polysaccharides and gastrodigenin. It exerts the effects of extinguishing wind and relieving convulsions， calming liver yang， dispelling wind and unblocking collaterals， which is highly consistent with the traditional Chinese medicine pathogenesis of hypertension. This paper systematically reviews the pharmacological effects and molecular mechanisms of active ingredients of Gastrodiae Rhizoma， herb pair compatibility， and classic prescriptions in hypertension. It is found that Gastrodiae Rhizoma and its active ingredients can collaboratively exert antihypertensive effects by regulating hemodynamics， oxidative stress， inflammatory response and other pathways， alleviate hypertensive vascular injury， and ameliorate damage to target organs including the heart， brain and kidney induced by hypertension. Compatibility of Gastrodiae Rhizoma with medicinal materials such as Uncaria， Chuanxiong， and Danshen produces remarkable synergistic efficacy against hypertension. Classic prescriptions containing Gastrodiae Rhizoma represented by Tianma gouteng decoction and Banxia baizhu tianma decoction can inhibit inflammation， resist oxidation， and protect vascular endothelium， so as to ameliorate hypertensive vascular injury and lower blood pressure.
