Research progress on the regulation of the tricarboxylic acid cycle by bioactive constituents of traditional Chinese medicine in the anti-atherosclerotic process
- VernacularTitle:中药活性成分调控三羧酸循环抗动脉粥样硬化的研究进展
- Author:
Yukai SU
1
;
Yajie ZHANG
1
;
Nana ZHANG
1
;
Chang LIU
1
;
Hongzhen YIN
2
;
Yumin YANG
3
Author Information
1. College of Clinical Chinese Medicine，Inner Mongolia Medical University，Hohhot 010110，China
2. Cancer Center，Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine，Hohhot 010020，China
3. Clinical Research Laboratory of Geriatric Diseases，Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine，Hohhot 010020，China
- Publication Type:Journal Article
- Keywords:
bioactive constituents of traditional Chinese medicine;
atherosclerosis;
tricarboxylic acid cycle;
inflammation;
oxidative stress;
glucolipid metabolism;
metabolic reprogramming
- From:
China Pharmacy
2026;37(13):1784-1790
- CountryChina
- Language:Chinese
-
Abstract:
The development of atherosclerosis （AS） is closely associated with endothelial dysfunction and mitochondrial metabolic abnormalities. These alterations are fundamentally characterized by metabolic reprogramming， in which the tricarboxylic acid （TCA） cycle serves as a central regulatory hub. Disruption of the homeostasis of TCA cycle intermediates， including succinate， α -ketoglutarate， and itaconate， contributes to AS progression through multiple mechanisms， such as the modulation of oxidative stress， inflammation， and glucose and lipid metabolic networks. Owing to their multi-target and multi-pathway regulatory properties， bioactive compounds derived from traditional Chinese medicine （TCM） have demonstrated unique advantages in correcting metabolic dysregulation. Flavonoids， glycosides， and other bioactive constituents of TCM can target key enzymes and metabolites involved in the TCA cycle， thereby restoring aberrant metabolic reprogramming， alleviating endothelial injury induced by oxidative stress， inflammation， and glucose and lipid metabolic disorders， ultimately improving metabolic homeostasis and attenuating the progression of AS.
