Research progress on regulation of antitumor immune function of γδ T cells by active ingredients of traditional Chinese medicine
- VernacularTitle:中药活性成分调控γδT细胞抗肿瘤免疫功能的研究进展
- Author:
Binrui WANG
1
;
Zheng CHANG
2
;
Meijing QIN
2
;
Limei ZHAO
2
;
Juanmei MO
3
;
Xiang LU
4
;
Chunhua LU
1
Author Information
1. Zhuang and Yao Medicine Research Laboratory，International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine，Nanning 530201，China
2. Medical Experiment Center，The First People’s Hospital of Nanning （The Fifth Affiliated Hospital of Guangxi Medical University），Nanning 530022，China
3. Dept. of Oncology，International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine，Nanning 530201，China
4. Dept. of Hematology，The First People’s Hospital of Nanning （The Fifth Affiliated Hospital of Guangxi Medical University），Nanning 530022，China
- Publication Type:Journal Article
- Keywords:
γδ T cell;
traditional Chinese medicine;
active ingredient;
antitumor;
immunotherapy;
immune escape
- From:
China Pharmacy
2026;37(13):1773-1777
- CountryChina
- Language:Chinese
-
Abstract:
γδ T cells possess both innate and adaptive immune characteristics. Their antigen recognition is independent of major histocompatibility complex presentation， and they can directly recognize abnormal tumor metabolism， showing unique application potential in tumors with low immune infiltration. This paper systematically sorts out the biological characteristics and antitumor immune functions of γδ T cells， and mainly reviews the relevant mechanisms by which active ingredients of traditional Chinese medicine regulate γδ T cells to exert antitumor immune functions. Glycyrrhiza polysaccharide and Astragalus polysaccharide can enhance the antitumor immune function of γδ T cells by promoting the expression of various cytokines， regulating intestinal flora and alleviating immunosuppressive state. Quercetin and puerarin can strengthen γδ T cell-mediated tumor cell killing by regulating the proliferation of γδ T cells， the expression of cytotoxic effector molecules and related signaling pathways. Toosendanin can potentiate γδ T cell-induced tumor cell killing by down-regulating the expression of anti-apoptotic protein in tumor cells. Artesunate can boost γδ T cell-mediated antitumor immune responses by enhancing the effector function of γδ T cells and weakening tumor immune escape. Future research shall focus on exploring the synergistic effects and molecular mechanisms of the combined application of active ingredients of traditional Chinese medicine and γδ T cell immunotherapy， and identifying the key targets for γδ T cells to exert antitumor immune functions.
