Research progress on pharmacological activities and mechanisms of farrerol
- VernacularTitle:杜鹃素药理活性及作用机制研究进展
- Author:
Siyuan XI
1
;
Yin MA
2
;
Yingying LIANG
1
;
Wenwen LIAN
1
;
Bingzhi MA
1
;
Jun HE
1
Author Information
1. Dept. of Pharmacy，China- Japan Friendship Hospital，Beijing 100029，China
2. Dept. of Pharmacy，Beijing Ditan Hospital，Capital Medical University，Beijing 100015，China
- Publication Type:Journal Article
- Keywords:
farrerol;
pharmacological activity;
mechanism;
cardiovascular and cerebrovascular;
anti-tumor
- From:
China Pharmacy
2026;37(13):1768-1772
- CountryChina
- Language:Chinese
-
Abstract:
Farrerol is a dihydroflavone compound extracted from the dried leaves of Rhododendron dauricum belonging to the Ericaceae family. This article systematically reviews relevant research on farrerol both domestically and internationally， summarizes its pharmacological activities and mechanisms of action， and finds that it exerts cardiovascular and cerebrovascular protective effects by maintaining the homeostasis of vascular endothelial function and inhibiting vascular intimal hyperplasia； exerts renal protective effects by activating the nuclear factor erythroid 2-related factor 2 （Nrf2） signaling pathway to reduce renal damage； exerts liver protective effects by inhibiting the phosphatidylinositol 3-kinase/protein kinase B signaling pathway， activating the Nrf2 signaling pathway， improving insulin resistance， and reducing lipid deposition in the liver； exerts neuroprotective effects by activating the Nrf2/Keap1 signaling pathway， inhibiting the Toll-like receptor 4 and cyclic GMP-AMP synthase/stimulator of interferon genes signaling pathways to reduce neuroinflammatory damage； exerts bone protective effects by promoting tendon formation and inhibiting osteoclast differentiation； exerts antitumor effects by inducing tumor cell apoptosis and weakening tumor cell invasion and metastasis； and exerts antibacterial effects by downregulating α -toxin expression， interfering with β -lactamase/penicillin-binding protein 2a （PBP2a）， and inhibiting PBP2a oligomerization. Currently， research on the pharmacological effects of farrerol is still mainly focused on animal and cell experiments. Further mechanistic studies and clinical trials are needed to provide theoretical basis for its new drug development and clinical application.
