Modern research progress on the pharmacological effects and clinical applications of Xuefu zhuyu decoction
- VernacularTitle:血府逐瘀汤药理作用与临床应用的现代研究进展
- Author:
Yihang SHEN
1
;
Baojun JU
2
;
Xiao LI
2
;
Miaomiao MA
1
;
Kang XU
1
;
Gentao ZHANG
2
Author Information
1. Dept. of Andrology，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China;The First Clinical College of Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Dept. of Andrology，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
- Publication Type:Journal Article
- Keywords:
Xuefu zhuyu decoction;
blood-absorbed components;
pharmacological effect;
clinical application;
treating different diseases with the same approach
- From:
China Pharmacy
2026;37(13):1762-1767
- CountryChina
- Language:Chinese
-
Abstract:
Xuefu zhuyu decoction is a classic formula for promoting blood circulation and resolving blood stasis， characterised by its remarkable ability to treat different diseases with the same approach. Qi stagnation and blood stasis， the primary syndrome for which this formula is indicated， has been found through modern medical research to be intrinsically linked to a wide range of pathophysiological processes， including microcirculatory disorders， abnormalities in hemorheology， inflammatory responses and endothelial dysfunction； which opens up vast scope for the innovative application of traditional formulas. In terms of pharmacological effect and mechanism， the formula exerts a synergistic regulatory effect across multiple key pathological pathways， including the regulation of coagulation function， the maintenance of vascular structure and function， anti-inflammatory and immunomodulatory actions， the mitigation of oxidative stress， and the modulation of programmed cell death （such as pyroptosis and ferroptosis）. This systematically demonstrates its scientific rationale， which is based on integrated regulation through multiple constituents， multiple targets and multiple pathways. In terms of clinical application， the formula has expanded from cardiovascular diseases to multiple disciplines， including gastroenterology， respiratory medicine， urology， neurology， endocrinology， gynaecology and andrology， with evidence-based medical evidence continuing to accumulate. Current research still faces bottlenecks such as a relatively low level of clinical evidence， insufficient systems biology analysis of the mechanisms underlying the compound’s formulation， and a weak correlation between quality control indicators and therapeutic efficacy. Future efforts should focus on conducting multicentre randomised controlled trials for conditions where the formula demonstrates particular efficacy， deepening research into the relationship between integrated pharmacology and spectrum-efficacy relationship， and promoting the precise application and formulation innovation of classical herbal formulas.
