Efficacy of radiofrequency ablation for hepatocellular carcinoma guided by both low-dose spiral computed tomography and ultrasound
10.13491/j.issn.1004-714X.2026.02.009
- VernacularTitle:低剂量螺旋CT联合超声引导肝癌射频消融的疗效分析
- Author:
Chaoqun MA
1
Author Information
1. Department of Ultrasound Medicine, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou 221000, China.
- Publication Type:OriginalArticles
- Keywords:
Hepatocellular carcinoma;
Radiofrequency ablation;
Low-dose spiral computed tomography;
Ultrasound guidance;
Efficacy;
Prognosis analysis
- From:
Chinese Journal of Radiological Health
2026;35(2):214-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of radiofrequency ablation for hepatocellular carcinoma (HCC) guided by both low-dose spiral computed tomography (CT) and ultrasound. Methods A retrospective analysis was conducted on 126 HCC patients treated at Xuzhou Hospital of Traditional Chinese Medicine between January 2022 and June 2024. Patients were divided into a control group (n=52, radiofrequency ablation guided by ultrasound) and an observation group (n=74, radiofrequency ablation guided by both low-dose spiral CT and ultrasound). The two groups were compared for ablation outcomes, surgical parameters, liver function indicators, tumor markers, complication rates, and short-term prognosis. Results The first puncture success rate (94.59% vs. 82.69%) and the complete ablation rate (95.95% vs. 84.62%) were significantly higher in the observation group than in the control group (P<0.05). The ablation safety margin was significantly larger in the observation group than in the control group [(0.72 ± 0.20) cm vs. (0.59 ± 0.20) cm, P<0.05]. In the observation group, the procedure time was significantly shorter [(67.45 ± 15.23) min vs. (82.31 ± 18.76) min, P<0.05], and the intraoperative blood loss was significantly less [(10.27 ± 4.96) mL vs. (12.45 ± 5.83) mL, P<0.05], as compared with those in the control group. The alanine aminotransferase and aspartate aminotransferase levels at 1 month post-operation and the alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II levels at 3 months post-operation were significantly lower in the observation group than in the control group (P<0.05). The complication rate was significantly lower in the observation group than in the control group (5.41% vs. 17.31%, P<0.05). The local recurrence rates at 3 and 6 months were significantly lower in the observation group than in the control group (P<0.05). There was no significant difference in the 6-month survival rate between the two groups (P>0.05). The average radiation dose in the observation group was (2.85 ± 0.67) mSv. Conclusion Radiofrequency ablation for HCC guided by both low-dose spiral CT and ultrasound demonstrates superior ablation outcomes, shorter surgical time, less intraoperative blood loss, less liver function damage, fewer complications, and lower local recurrence rates. While maintaining therapeutic effectiveness, this approach effectively controls radiation dose and is worthy of clinical application.
