Application of mammography and magnetic resonance imaging in different molecular subtypes of breast cancer
10.13491/j.issn.1004-714X.2026.02.004
- VernacularTitle:乳腺钼靶和MRI在不同分子分型乳腺癌中的应用
- Author:
Jie JIANG
1
;
Xia XIE
1
Author Information
1. Radiology Department, North Hospital of Yongzhou Central Hospital, Yongzhou 425000, China.
- Publication Type:OriginalArticles
- Keywords:
Breast cancer;
Molecular typing;
Mammography;
Magnetic resonance;
Detection rate
- From:
Chinese Journal of Radiological Health
2026;35(2):180-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the imaging features and diagnostic value of mammography and magnetic resonance imaging (MRI) in different molecular subtypes of breast cancer. Methods A total of 126 breast cancer patients treated between January 2023 and January 2025 were enrolled, including 36 cases of Luminal A, 30 cases of Luminal B, 32 cases of HER-2 overexpression, and 28 cases of triple-negative breast cancer. The mammographic and MRI features, as well as the detection rates of mammography and MRI, were compared among the different molecular subtypes. Results The proportion of triple-negative breast cancers presenting as masses on mammography was higher than those of other subtypes (P<0.05), while the proportion of calcification was lower than other subtypes (P<0.05). Luminal A tumors showed a lower proportion of masses with indistinct margins on mammography compared with other subtypes (P<0.05), but a higher proportion of spiculated margins compared with HER-2 overexpression and triple-negative subtypes (P<0.05). On MRI, the proportion of triple-negative breast cancers presenting as masses was higher than those of other subtypes (P<0.05). The apparent diffusion coefficients of Luminal A and Luminal B breast cancers were higher than those of other subtypes (P<0.05). The detection rate of Luminal B breast cancer was higher on MRI than that on mammography (P<0.05). Conclusion Mammographic and MRI features differed significantly among molecular subtypes of breast cancer. Both mammography and MRI showed high detection rates across subtypes, with MRI demonstrating a higher detection rate than mammography in Luminal B breast cancer.
