Global advances in focal therapy for prostate cancer and the Fudan experience
10.12483/j.issn.1009-8291.2026.06.001
- VernacularTitle:前列腺癌局灶治疗的国际进展与复旦经验
- Author:
Yao ZHU
1
;
Xiyue XIAO
1
;
Junlong WU
1
;
Dingwei YE
1
Author Information
1. Department of Urology, Fudan University Shanghai Cancer Center
- Publication Type:Journal Article
- Keywords:
prostate cancer;
focal therapy;
irreversible electroporation;
functional preservation;
precision medicine
- From:
Journal of Modern Urology
2026;31(6):497-502
- CountryChina
- Language:Chinese
-
Abstract:
The management of localized prostate cancer requires a balance between oncological control and functional preservation.Focal therapy, as an emerging strategy between radical treatment and active surveillance, enables precise tumor ablation based on multiparametric magnetic resonance imaging, prostate-specific membrane antigen (PSMA) -guided imaging and targeted biopsy.Techniques including cryotherapy, high-intensity focused ultrasound, irreversible electroporation, and vascular-targeted photodynamic therapy have demonstrated favorable functional outcomes in short-to mid-term follow-up. However, their long-term efficacy and optimal indications remain to be verified.This article summarizes recent international advances in focal therapy for prostate cancer and introduces the “Penta-Managing System” developed by the multidisciplinary urology team at Fudan University Shanghai Cancer Center based on the full-process application of irreversible electroporation, providing insights for the standardized and individualized use of focal therapy.
