Renal mucinous tubular and spindle cell carcinoma: a diagnostic and therapeutic analysis of 14 cases
10.12483/j.issn.1009-8291.2026.05.004
- VernacularTitle:肾脏黏液性小管状和梭形细胞癌14例诊治分析
- Author:
Ning DONG
1
;
Yulin ZHOU
2
;
Wenyi HUANG
3
;
Xiaoxu JIN
3
;
Xiaodong ZHAO
2
;
Jie DONG
2
;
Song XU
4
Author Information
1. Jinling Clinical Medical College, Nanjing Medical University, Nanjing 210002
2. Department of Urology, Eastern Theater Command General Hospital, Nanjing 210002
3. Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China
4. Jinling Clinical Medical College, Nanjing Medical University, Nanjing 210002; Department of Urology, Eastern Theater Command General Hospital, Nanjing 210002; Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China
- Publication Type:Journal Article
- Keywords:
mucinous tubular and spindle cell carcinoma;
imaging features;
immunohistochemistry;
differential diagnosis;
prognosis
- From:
Journal of Modern Urology
2026;31(5):422-427
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical, imaging, pathological characteristics and prognosis of renal mucinous tubular and spindle cell carcinoma (MTSCC), so as to provide preference for the differential diagnosis and clinical management of this disease.Methods A retrospective analysis was conducted on the clinical and follow-up data of 14 patients diagnosed with renal MTSCC at the Eastern Theater Command General Hospital during June 2021 and Aug.2025.Relevant literature was reviewed.Results Of the 14 patients, 10 were female (71.4%) and 4 were male (28.6%), with a mean age of 56.9 years. Pathological staging included pT1a in 6 cases, pT1b in 7 cases, and pT2b in 1 case.The median tumor diameter was 4.5 (range 2.0-11.0) cm.Twelve cases (85.7%) were asymptomatic and detected incidentally.On ultrasonography, most tumors exhibited well-defined margins and regular morphology (9/10, 90%) and appeared as homogeneous hypoechoic masses (7/10, 70%).All lesions demonstrated hypovascular features on imaging studies.Ten patients (71.4%) underwent laparoscopic radical nephrectomy, and 4(28.6%) received partial nephrectomy.Histologically, a distinctive architecture composed of tubular structures, spindle-shaped cells, and mucinous stroma was exhibited.Immunohistochemically, the positive rates of PAX-8, VIMENTIN and CK7 in tumor cells were 100% (13/13), 91.7% (11/12) and 84.6% (11/13), respectively.The Ki-67 proliferation index ranged from 2.0% to 40.0%.During a median follow-up of 25.0 (range4.9-0.0) months, no local recurrence or distant metastasis was observed.Conclusion Renal MTSCC is a rare subtype of renal cell carcinoma, typically lacking specific clinical symptoms and characterized by hypovascular imaging features.The tumor generally follows an indolent course with a favorable prognosis.For localized tumors, partial nephrectomy should be the primary consideration.For cases with high-risk pathological features such as sarcomatoid changes, due attention should be paid to the potential invasiveness and follow-up should be closely conducted.
