The roles and molecular mechanisms of mechanosensitive ion channel Piezo1 in urinary tract fibrosis
10.12483/j.issn.1009-8291.2026.01.014
- VernacularTitle:机械敏感离子通道Piezo1在尿路纤维化中的作用及其分子机制
- Author:
Tianmeng GAO
1
;
Chi ZHANG
1
;
Qingli ZHANG
1
;
Wanxin ZHANG
1
;
Yubo GU
2
;
Lujie SONG
2
Author Information
1. Shanghai Jiao Tong University School of Medicine, Shanghai 200025
2. Department of Urology, Shanghai Sixth Peopleˊs Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233; Shanghai Eastern Institute of Urologic Reconstruction, Shanghai 200233, China
- Publication Type:Journal Article
- Keywords:
Piezo1;
urinary tract fibrosis;
urinary tract obstruction;
signal pathway
- From:
Journal of Modern Urology
2026;31(1):78-83
- CountryChina
- Language:Chinese
-
Abstract:
The high pressure generated from urinary tract obstruction can cause damage to the tissues and cells of the urinary tract. Persistent damage can induce urinary tract fibrosis, ultimately resulting in the loss of urinary tract function and severe clinical problems. In recent years, the role of a novel mechanosensitive ion channel in urinary tract fibrosis, Piezo1, has drawn due attention. This review systematically summarizes the mechanisms of Piezo1. In upper urinary tract fibrosis, Piezo1 participates in fibrotic process through the Calcium-Calpain2-integrin β1-adhesion protein pathway and Piezo1-p38MAPK-YAP signaling pathway. In lower urinary tract fibrosis, Piezo1 mediates bladder fibrosis via the YAP1 and TGF-β1/Smad pathways, and may contribute to prostate cancer-associated urethral obstruction through the Akt/mTOR signaling pathway. This study elucidates the critical roles of Piezo1 in urinary tract fibrosis, providing a theoretical foundation for developing novel Piezo1targeted therapeutic strategies. Future research can leverage advanced technologies such as microfluidic organ-on-a-chip system to explore the precise regulatory mechanisms of Piezo1, thus offering new insights for the clinical management of urinary stricture diseases.
