Intravesical instillation of urokinase plus heparin sodium for bladder clot irrigation:preliminary experience with 3 cases
10.12483/j.issn.1009-8291.2026.01.011
- VernacularTitle:尿激酶联合肝素钠膀胱灌注治疗膀胱血凝块填塞3例报告初步经验
- Author:
Qi'ao JING
1
;
Shengtong YE
1
;
Jiaying SONG
1
;
Tongjingzhi LIN
1
;
Qi ZHANG
1
;
Zicheng LI
1
;
Yang SU
2
;
Zhihui ZOU
3
;
Chaozhao LIANG
3
Author Information
1. The First Clinical College of Anhui Medical University, Hefei 230022
2. Department of Urology, The First Affiliated Hospital of Anhui Medical University/Institute of Urology, Anhui Medical University/Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation/Anhui Clinical Research Center of Urinary System Diseases, Hefei 230022, China
3. The First Clinical College of Anhui Medical University, Hefei 230022; Department of Urology, The First Affiliated Hospital of Anhui Medical University/Institute of Urology, Anhui Medical University/Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation/Anhui Clinical Research Center of Urinary System Diseases, Hefei 230022, China
- Publication Type:Journal Article
- Keywords:
urokinase;
heparin sodium;
bladder clot;
bladder clot irrigation;
thrombolysis
- From:
Journal of Modern Urology
2026;31(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility of intravesical instillation of urokinase and heparin sodium in the treatment of bladder clot irrigation.Methods This report discusses the diagnosis and treatment of three patients with bladder blood clot tamponade confirmed by abdominal and pelvic computed tomography(CT)scans enrolled from our hospital during Jun. to Sep. 2024, and discuss the relevant literature.Results A solution containing urokinase(20 000 IU)and heparin sodium(125 000 U)was instilled through a three-way catheter and retained for 30 minutes before drainage. Complete clot dissolution was achieved in all cases, with immediate relief of hypogastric distension and pain. Post-procedural CT showed restored bladder lumen patency. Hemoglobin levels decreased by 2-5 g/L without complications.Conclusion This preliminary trial demonstrated that intravesical instillation of urokinase-heparin provides a safe and effective minimally invasive alternative for bladder clot in irrigation cases.
