Clear cell renal cell carcinoma with parotid gland metastasis 10 years after radical nephrectomy: a case report and literature review
10.12483/j.issn.1009-8291.2026.01.008
- VernacularTitle:肾癌根治术后10年腮腺肾透明细胞癌转移1例报告并文献复习
- Author:
Hongjun LIU
1
;
Chenxu MA
1
;
Xueping ZHANG
2
;
Feng HAN
2
;
Yuan GAO
2
;
Hongjun ZHAO
2
;
Liang QIAO
2
Author Information
1. School of Clinical Medicine, Shandong Second Medical University, Weifang 261000; Department of Urology, Weifang People's Hospital, Weifang 261000, China
2. Department of Urology, Weifang People's Hospital, Weifang 261000, China
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
clear cell renal cell carcinoma;
parotid gland metastasis
- From:
Journal of Modern Urology
2026;31(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the diagnosis, treatment and clinical characteristics of a patient with parotid gland metastasis of clear cell renal cell carcinoma(ccRCC)following radical nephrectomy. Methods The clinical data and diagnostic/therapeutic course of the patient were reported, and the metastasis time and treatment methods of patients with parotid metastasis of renal cancer were summarized in combination with literature. Results The 63-year-old male patient sought medical help due to a mass behind the right ear persisting for 3 months. He had undergone a right radical nephrectomy for a renal tumor 10 years ago. Preoperative computed tomography(CT)with contrast of the parotid region revealed an approximately 2.5 cm×2.1 cm round soft-tissue density lesion in the right parotid gland with slightly irregular margins. Positron emission tomography/computed tomography(PET/CT)showed an enlarged left kidney with an irregular shape and multiple round, slightly hyperdense lesion(SUVmax=7.2), suggestive of malignancy. A round, slightly hyperdense lesion(diameter 2.6 cm, SUVmax=4.2)with well-defined borders and increased radiotracer uptake was noted in the right parotid gland, indicating a hypermetabolic mass where malignancy could not be excluded. The patient subsequently underwent partial parotidectomy, advancement flap transplantation, and facial nerve dissection. Postoperative pathology revealed tumor cells with clear/eosinophilic cytoplasm and nuclear atypia, exhibiting ill-defined borders with salivary gland tissue. Immunohistochemistry was positive for PAX-8, CAⅨ, and Ki-67. During the 12-month follow-up, the patient was in good condition with no evidence of tumor recurrence or metastasis. Conclusion Parotid gland metastasis following radical nephrectomy is exceedingly rare, with no specific imaging features and clinical manifestations, and definitive diagnosis relies on pathological examination. Currently, there is no standardized treatment protocol, but complete surgical excision remains the primary therapeutic option.
