Research progress on the pathological mineralization mechanism of kidney stones and the association with systemic calcification
10.12483/j.issn.1009-8291.2026.03.014
- VernacularTitle:肾结石病理矿化机制及其与全身性钙化的关联研究进展
- Author:
Luejun SHI
1
;
Sixing YANG
1
;
Yunhe XIONG
1
Author Information
1. Department of Urology, Renmin Hospital of Wuhan University, Hubei Provincial Clinical Research Center for Urolithiasis, Wuhan 430060, China
- Publication Type:Journal Article
- Keywords:
pathological mineralization;
kidney stones;
Randall's plaque;
ectopic calcification
- From:
Journal of Modern Urology
2026;31(3):277-282
- CountryChina
- Language:Chinese
-
Abstract:
Kidney stones are a typical model of pathological mineralization, and the association between local mineralization imbalance and systemic ectopic calcification is complex. This review systematically summarizes three major advances in the field. Firstly, at the molecular level, inflammatory/immune modulation(Th-cell activation), metabolic dysregulation(aberrant calcium-phosphate/lipid metabolism), and epigenetic control(lncRNA-driven osteogenic differentiation)act in concert to drive Randall's plaque formation. Secondly, at the systemic level, nephrolithiasis shares the Klotho pathway with vascular calcification and bone-metabolic disorders, converging on the inhibition of Wnt/β-catenin and related axes, underscoring the global impact of calcium-phosphate homeostatic disruption. Thirdly, in translational medicine, GeoBioMed technologies dissect mineral heterogeneity, AI models predict recurrence risk(AUC=0.87), CRISPR-based interventions [silencing of metastasisassociated lung adenocarcinoma transcript 1(MALAT1)], and biomimetic materials(carbonate-apatite coatings)exhibit significant therapeutic promise. Future efforts should integrate single-cell multi-omics, microbiome modulation, and cross-organ dynamic monitoring to shift the therapeutic paradigm from stone removal to the precise restoration of mineralization homeostasis.
