An in vitro experimental study on the efficiency of dissolving pediatric ammonium urate stones in solutions with different pH values
10.12483/j.issn.1009-8291.2026.03.007
- VernacularTitle:不同酸碱度溶液溶解儿童尿酸铵结石的效率：一项体外实验研究
- Author:
Ningkang ZOU
1
;
Dong LIU
2
;
Bide LIU
1
;
Jiuzhi LI
1
;
Yukui NAN
1
;
Yusufu AINIWAER
1
;
Peixin ZHANG
1
;
Weili DU
1
;
Chi YUAN
3
;
Hongliang JIA
1
Author Information
1. Urological Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001
2. Department of Urology, Children's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000
3. Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
- Publication Type:Journal Article
- Keywords:
urinary stone;
ammonium urate;
child;
dissolution experiments;
pH value;
sodium chloride solution;
artificial urine
- From:
Journal of Modern Urology
2026;31(3):240-243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the dissolution effects of pediatric ammonium urate stones in solutions with different pH values, so as to provide reference for the clinical treatment of this type of stones. Methods Eight pure ammonium urate stones(ammonium urate content ≥90%)of similar size and mass(median mass 4.6 g)were obtained from 8 children(＜14 years)undergoing percutaneous nephrolithotomy at the People's Hospital of Xinjiang Uygur Autonomous Region. The stones were placed in sodium chloride solutions with pH values of 5.0, 6.0, 7.0, and 8.5 and artificial urine with pH values of 4. 6, 5.0, 7.0, and 8.5 at a constant temperature of 37 ℃. The mass of the stones was recorded before placement and at 24, 48, and 72 h after placement. The dissolution rates of the stones were calculated. Results The pediatric ammonium urate stones could be dissolved in sodium chloride solution, and the total dissolution rate was the highest(94.6%)after 72 hours when the pH value was 6.0. The total dissolution rate of ammonium urate stones in artificial urine after 72 hours were all over 50%, and the total dissolution rate was the highest(79.7%)when the pH value was 4.6. Conclusion Pediatric ammonium urate stones are soluble in sodium chloride solution and artificial urine, and the total dissolution rate is higher in acidic environment.
