Blood glucose lowering effect of herbal formulations in a rat model of diabetes
- VernacularTitle:Ургамлын найрлагатай бэлдмэлүүдийн цусан дахь глюкозыг бууруулах нөлөөг харханд үүсгэсэн чихрийн шижингийн эмгэг загварт судалсан дүн
- Author:
Davaasambuu Tegshbayar
1
;
Oyunchimeg Bayaraa
1
;
Maral Lkhagva
1
;
Batdorj Davjid
1
;
Badamtsetseg Soyollkham
1
;
Lkhaasuren Ryenchindorj
1
;
Tsetsegmaa Sanjjav
1
;
Khurelbaatar Luvsan
2
Author Information
1. Department of Pharmacology, Drug research institute, Ulaanbaatar, Mongolia
2. Department of Pharmacology, Drug research institute, Ulaanbaatar, Mongolia; Monos Group, Ulaanbaatar, Mongolia
- Publication Type:Journal Article
- Keywords:
Banaba;
Lagerstroemia speciosa;
Jerusalem artichoke;
Helianthus tuberosus;
Shrubby cinquefoil;
Dasiphora fruticosa;
alloxan-induced diabetes;
antihyperglycemic activity
- From:
Mongolian Pharmacy and Pharmacology
2026;28(1):77-84
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due
to impaired insulin secretion or action. The global prevalence of DM is increasing rapidly, threatening public health and quality of life. In Mongolia, the incidence of type 2 diabetes mellitus (T2DM) has shown a continuous upward trend, highlighting the need for effective plant-derived formulations with glucose-lowering potential.
This study aimed to evaluate the antihyperglycemic effect of composite formulations containing Lagerstroemia speciosa L. (Banaba), Helianthus tuberosus L., and Dasiphora fruticosa L. in alloxan-induced diabetic rats.
Methods:T2DM was induced in Wistar rats by intraperitoneal injection of alloxan monohydrate (170 mg/kg). The rats were divided into seven groups: Group 1: healthy control, Group 2: diabetic control, Group 7: metformin-treated (40 mg/200 g), and four treatment groups (Groups 3-6) receiving different combinations of Banaba, Jerusalem artichoke, and Shrubby cinquefoil extracts for 19 consecutive days. Blood glucose levels were measured daily using a GluNeo® Lite glucometer.
After 19 days, animals in Group and Group 6 exhibited significant reductions in blood glucose levels compared with the diabetic (Group 2) and metformin-treated (Group 7) controls (p<0.01). Group 5 demonstrated the greatest hypoglycemic effect, reducing glucose levels by 43.4% relative to the diabetic control group (Group 2).
Conclusion:Composite formulations containing Banaba, Helianthus tuberosus L., and Dasiphora fruticosa L.
exhibited significant antihyperglycemic activity in alloxan-induced diabetic rats. The formulation with Banaba (24 mg) + Helianthus tuberosus L. (200 mg) + Dasiphora fruticosa L. (100 mg) showed the most potent glucose-lowering effect, comparable to metformin, indicating its potential as a promising herbal formulation for T2DM management.
- Full text:2026080200264501228MPPJ-2026-28(1)-77-84.pdf
