Association of Testosterone With Insulin Resistance and Beta-Cell Function in Type 2 Diabetes Mellitus
https://doi.org/10.15605/jafes.041.S1
- Author:
Khoirun Mukhsinin Putra
1
;
Yulianto Kusnadi
1
;
Ratna Maila Dewi
1
;
Alwi Shahab
1
Author Information
1. Division of Endocrinology, Metabolism, and Diabetes, Faculty of Medicine, Sriwijaya University/Dr. Mohammad Hoesin General Hospital, Indonesia
- Publication Type:Journal Article
- MeSH:
Diabetes Mellitus, Type 2;
Insulin Resistance;
Testosterone
- From:
Journal of the ASEAN Federation of Endocrine Societies
2026;41(S1):56-57
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Insulin resistance and progressive beta-cell dysfunction
are key components of the pathophysiology of type
2 diabetes mellitus (T2DM). The triglyceride-to-highdensity lipoprotein cholesterol (TG/HDL) ratio has been
widely used as a marker of insulin resistance. In addition,
testosterone deficiency has been associated with adverse
metabolic profiles and T2DM. However, the relationship
between testosterone levels, insulin resistance, and betacell function in patients with T2DM remains incompletely
understood.
Methodology:A cross-sectional study was conducted involving 25 male
patients with T2DM attending the diabetic clinic at Dr.
Mohammad Hoesin General Hospital. Serum testosterone,
C-peptide, TG, and HDL levels were obtained from routine
clinical data. The TG/HDL ratio was calculated as an index
of insulin resistance. Normality was assessed using the
Shapiro–Wilk test, and due to the non-normal distribution
of key variables, Spearman correlation analysis was
applied.
Results:A strong inverse correlation was observed between
testosterone levels and TG/HDL ratio (r = -0.860, p <0.001),
indicating that higher insulin resistance was associated
with lower testosterone levels. In addition, TG/HDL ratio
showed a strong negative correlation with C-peptide levels
(r = -0.741, p <0.001), suggesting reduced beta-cell function
in the presence of increased insulin resistance.
Conclusion:In patients with T2DM, increased insulin resistance is
strongly associated with lower testosterone levels and
reduced beta-cell function. These findings highlight the
interaction between metabolic dysfunction and hormonal
status in middle-aged and elderly patients with T2DM
- Full text:2026073016390582390EP_A068.pdf
