A Unique Familial Cluster of Type 1 Diabetes: Clinical Course and Treatment Considerations
https://doi.org/10.15605/jafes.041.S1
- Author:
Kian Guan Goh
1
Author Information
1. KMI Kuantan Medical Centre
- Publication Type:Journal Article
- MeSH:
Diabetes Mellitus, Type 1;
Disease Progression
- From:
Journal of the ASEAN Federation of Endocrine Societies
2026;41(S1):55-
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Familial type 1 diabetes occurs up to 10% in large databases.
This case series illustrated a family with three new onset
type 1 diabetes diagnosed due to elevated blood sugar
and positive diabetes autoantibody.
Case:The index case was a 15-year-old male who presented with
progressive osmotic symptoms over 1 month in 2024. He
was admitted for severe diabetic ketoacidosis (DKA). Initial
hemoglobin A1c (HbA1c) was 10.7%, and anti-GAD was
>2,000 IU/mL. He was treated with basal bolus insulin.
The youngest brother was a 12-year-old male, presented
with osmotic symptoms for 1 week in 2025. Random blood
glucose elevated to 36 mmol/L. HbA1c was 8.9%. AntiGAD was >2,000 IU/mL. He was admitted with impending
DKA and discharged with basal bolus insulin.
The second brother was a 15-year-old male currently
asymptomatic. Random blood glucose was normal. AntiGAD was elevated at 1,307 IU/mL. Discussion regarding
teplizumab to prevent further progression to type 1
diabetes was halted due to high cost and limited availability
of the drug.
Conclusion:Active screening for siblings with diabetes autoantibodies
among siblings with type 1 diabetes should be considered.
Treatment with teplizumab for asymptomatic persons
should be considered.
- Full text:2026073016254626866EP_A065.pdf
