Prevalence of Diabetic Peripheral Neuropathy and Its Association With Serum Neuron-Specific Enolase Among Type 2 Diabetes Mellitus Patients
https://doi.org/10.15605/jafes.041.S1
- Author:
Siti Kaamilah Mohd Zin
1
;
Fatimah Zaherah Mohamed Shah
2
;
Nor Amelia Mohd Fauzi
3
;
Rohana Abdul Ghani
2
;
Nur ‘Aini Eddy Warman
2
Author Information
1. Hospital Tawau; Endocrine Unit, Department of Internal Medicine, Hospital Al-Sultan Abdullah, Universiti Teknologi MARA
2. Endocrine Unit, Department of Internal Medicine, Hospital Al-Sultan Abdullah, Universiti Teknologi MARA
3. Neurology Unit, Department of Internal Medicine, Hospital AlSultan Abdullah, Universiti Teknologi MARA
- Publication Type:Journal Article
- MeSH:
Humans;
Diabetes Mellitus, Type 2;
Diabetic Neuropathies;
Prevalence;
Phosphopyruvate Hydratase
- From:
Journal of the ASEAN Federation of Endocrine Societies
2026;41(S1):33-
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:Diabetic peripheral neuropathy (DPN) is a common
complication of type 2 diabetes mellitus (T2DM), with
nerve conduction studies recognized as the diagnostic
gold standard. Serum neuron-specific enolase (NSE) has
been linked with DPN. This study aims to determine the
prevalence of DPN among T2DM patients, evaluate clinical
characteristics, and explore the relationship between NSE
and DPN.
Methodology:A cross-sectional study was conducted at Universiti
Teknologi MARA Specialist Centre Sungai Buloh and
Hospital Al-Sultan Abdullah, involving patients aged 18–60
years, diagnosed with T2DM for more than 5 years (n = 132).
All participants underwent anthropometric measurement,
completed the Michigan Neuropathy Screening Instrument
evaluation, and biochemical parameters, including lipid
profile, hemoglobin A1c, and serum creatine and NSE.
The diagnosis of DPN was made based on positive NCS
findings. Logistic regression was used to identify factors
associated with DPN.
Results:The study population had a mean age of 60.16 ± 10.28 years
and a mean duration of diabetes of 14.82 ± 6.66 years. The
prevalence of DPN was 51.5% (n = 68). Serum NSE levels
were significantly higher (p = 0.003) and independently
associated with the presence of DPN (adjusted odds ratio
[OR] 1.033, 95% confidence interval [CI] 1.009–1.058, p =
0.006). Participants with DPN were also more likely to be
on insulin therapy (p = 0.040). In addition, retinopathy
(adjusted OR 3.567, 95% CI 1.528–8.329, p = 0.013) and
elevated Urine Albumin-to-Creatinine Ratio levels
indicating albuminuria (adjusted OR 1.031, 95% CI 1.002–
1.061, p = 0.037) were significantly associated with DPN.
Conclusion:More than half of the study population had DPN, which
was significantly associated with both retinopathy and
nephropathy, as well as with elevated serum NSE.
This emphasizes the importance of early screening and
highlights the role of NSE as a surrogate marker for
neuropathy in diabetes.
- Full text:2026072815312404198EP_A027.pdf
