HOARSENESS SECONDARY TO LARYNGEAL HISTOPLASMOSIS: A CASE REPORT
- Author:
Ahmad Mahfuz ZAMAILI
1
;
Irfan MOHAMAD
2
;
Hamidah MAMAT
3
;
Othman ABDULLAH
4
Author Information
1. Department of Otorhinolaryngology – Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus 16150 Kubang Kerian,Kelantan, Malaysia. Department of Otorhinolaryngology – Head & Neck Surgery, Hospital Sultan Abdul Halim, 08000 Sungai Petani, Kedah, Malaysia.
2. Department of Otorhinolaryngology – Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus 16150 Kubang Kerian,Kelantan, Malaysia
3. Department of Otorhinolaryngology – Head & Neck Surgery, Hospital Sultan Abdul Halim, 08000 Sungai Petani, Kedah, Malaysia
4. Department of Pathology, Hospital Sultan Abdul Halim, 08000 Sungai Petani, Kedah, Malaysia
- Publication Type:Case Reports
- Keywords:
Carcinoma;
Granulomatosis;
Histoplasmosis;
Larynx;
Tuberculosis
- From:
Brunei International Medical Journal
2022;18():16-19
- CountryBrunei Darussalam
- Language:English
-
Abstract:
Histoplasmosis usually occurs in immunocompromised patients through the dissemination of the fungus from lungs to other organs but laryngeal involvement is rare. We report a 52-year-old male chronic smoker who presented with hoarseness for 3 months was initially investigated for laryngeal carcinoma. However biopsy showed granulomatous inflammation. He was treated with anti-tuberculosis treatment for 2 months but symptoms persisted and a repeat biopsy revealed laryngeal histoplasmosis. There were no sign and symptoms of pulmonary or systemic involvement. Treatment with intravenous amphotericin B and oral itraconazole lead to complete resolution of symptoms and signs. Monitoring and early revisiting the diagnosis are important when a patient’s symptoms do not improve with the treatment. Further investigation including a repeat biopsy of lesion is vital to establish the diagnosis and lead to appropriate management.
- Full text:2026072311252863623BIMJ2022-18-16-19.pdf
