ACHROMOBACTER XYLOSOXIDANS BACTEREMIA IN A CHILD WITH X- LINKED AGAMMAGLOBULINEMIA
- Author:
Mohammad Qazreen AHMAD SHAWALUDIN
1
;
Mariana DAUD
2
;
Fazila MAT ARIFIN
2
;
Ilie Fadzilah HASHIM
3
;
Zarina Thasneem ZAINUDEEN
3
;
Adiratna MAT RIPEN
4
;
Fahisham TAIB
1
;
Intan Juliana ABD HAMID
3
Author Information
1. Department of Pediatric, Hospital Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia
2. Department of Pediatric, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia
3. Primary Immunodeficiency Diseases Group, Department of Clinical Medicine, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam 13200 Kepala, Batas, Pulau Pinang, Malaysia
4. Primary Immunodeficiency Unit, Allergy and Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Malaysia
- Publication Type:Case Reports
- Keywords:
X-linked agammaglobulinemia;
Bruton’s Disease;
Achromobacter xylosoxidans;
Immunological screening
- From:
Brunei International Medical Journal
2023;19():26-30
- CountryBrunei Darussalam
- Language:English
-
Abstract:
X-linked agammaglobulinaemia (XLA) is caused by mutation of the BTK gene. Early immunological screening is important in children with recurrent infection to avoid delay in diagnosis and treatment. A 9-year-old boy with delayed XLA diagnosis presented with a history of recurrent sinopulmonary infection since the age of 1 year old. He had a severe Achromobacter xylosoxidans bacteraemia at the age of 8 years that was successfully treated with intravenous antibiotics. Further immunological screening and genetic testing confirmed the diagnosis of XLA and he was treated with intravenous immunoglobulin replacement therapy. This case provides a valuable information on the diagnosis, treatment and management of XLA, emphasising the importance of early immunological investigations to avoid diagnostic delay.
- Full text:2026072215171254593BIMJ2023-19-26-30.pdf
