Comparative Study on the Protective Effect of Ascorbic Acid (Vitamin C) on Cannabis Sativa- Induced Oxidative Stress in Male and Female Wistar Rats
- Author:
Amuda Oluwasola
;
Olabisi Elizabeth Ayoola
;
Garba Sa'adu
- Publication Type:Journal Article
- Keywords:
cannabis sativa;
oxidative stress;
vitamin C;
sex dependent;
wistar rats
- From:
Pacific Journal of Medical Sciences
2026;27(2):3-11
- CountryPapua New Guinea
- Language:English
-
Abstract:
Consumption and legalization of Cannabis sativa (CS) are increasing at a rapid rate due to its medicinal
and recreational importance. However, several studies have revealed that CS stimulates oxidative stress
(OS) which could affect the antioxidant defense system of the body. This research examined and
compared the protective role of vitamin C (Vit C) on Cannabis sativa (CS)-induced oxidative stress in
male (M) and female (F)Wistar rats. Post-acclimation (14 days), M and F animals were separately
allocated to four groups. Males (1M, 2M, 3M, and 4M) and females (1F, 2F, 3F, and 4F) groups were
administered orally, 1.0 mL of distilled water (control), CS (4.0 mg/kg), Vit C (4.0 mg/kg) and CS (4.0
mg/kg) + Vit C (4.0 mg/kg) respectively, for 21 days. Glutathione peroxide (GPx), Superoxide dismutase
(SOD), Catalase, Glutathione reductase (GSH), Total antioxidant capacity (TAC), lactate dehydrogenase
(LDH), and Malondialdehyde (MDA) were quantified following standard protocols.
