Cannabis Sativa Exacerbates Inflammatory Responses In Male And Female Wistar Rats

Author: Olabisi Elizabeth Ayoola ; Amuda Oluwasola ; Garba Sa'adu
Publication Type:Journal Article
Keywords: Cannabis sativa; Inflammatory markers; Dose-dependent; Wistar rat
From: Pacific Journal of Medical Sciences 2025;27(1):50-55
CountryPapua New Guinea
Language:English
Abstract: Consumption of Cannabis sativa (CS) (Marijuana) has been known to be a psychoactive substance which has deleterious effects on the body cells. This study was conducted to investigate the inflammatory responses in male and female Wistar rats following administration of CS. Twenty male (m) and twenty female (f) rats were separately assigned into four groups of five animals each. The rats in groups 1m & If, 2m & 2f, 3m & 3f and 4m & 4f received orally 1mL of distilled water (control), 2mg/kg body weight (bw) of CS, 4mg/kgbw of CS and 6mg/kgbw of CS respectively for twenty-one (21) days. Inflammatory markers (C-reactive protein (CRP), Tumor necrosis factor (TNF), Interleukin-6 (IL-6), Myeloperoxidase (MPO), and Nitric oxide (NO)) were quantified using standard procedures. There was no significant (p>0.05) difference in CRP, TNF, IL-6, MPO, and NO in the groups treated with low dose of CS (2mg) but with significant (p<0.05) increase in high doses (4mg and 6mg) groups when compared with the control in both male and female rats.