Effect of co-administration of cannabis sativa and vitamin c on biomarkers of oxidative stress in female Wistar rats
- Author:
Amuda Oluwasola
;
Kolawole Yusuf
;
Lailat N Usman
;
Olanrewaju O Ayub
- Publication Type:Journal Article
- Keywords:
cannabis sativa;
vitamin C;
oxidative stress;
co-administration
- From:
Pacific Journal of Medical Sciences
2024;25(2):56-64
- CountryPapua New Guinea
- Language:English
-
Abstract:
By critically examining studies ranging from randomized controlled trials to meta-analyses and cross-
sectional studies, we seek to elucidate the potential benefits of vitamin C (vit. C) supplementation in
mitigating oxidative stress associated with cannabis (CS) consumption.
Twenty female rats with mean weight of (160 g ± 1.09) were separately assigned into four groups of five animals each. The rats in groups 1, 2, 3 and 4 respectively received orally 1.0 ml of distilled water
(control), 2.0mg/kg body weight (bw) CS+4mg/kg bw vit. C, 4.0mg/kgbw CS+4.0mg/kg bw vit. C and
6.0mg/kgbw CS+mg/4.0kg bw vit. C respectively for two weeks. All the groups have free access to food and water. All the rats were sacrificed on the 15th day. Lactate dehydrogenase (LDH), Catalase,
Glutathione reductase (GSH), Glutathione peroxide (GPx), Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC) were determined using standard methods.
