Tumor microenvironment heterogeneity and its regulatory mechanisms in renal cell carcinoma:the latest advances
10.12483/j.issn.1009-8291.2026.02.016
- VernacularTitle:肾细胞癌肿瘤微环境异质性及其调控机制研究进展
- Author:
Yu YANG
1
;
Ruijian LIU
2
;
Lulin MA
3
Author Information
1. Affiliated Ordos Clinical College, Inner Mongolia Medical University, Ordos 010013
2. Department of Urology, Ordos Central Hospital, Ordos 017000
3. Department of Urology, Peking University Third Hospital, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
tumor microenvironment;
tumor heterogeneity;
immunotherapy;
single-cell sequencing;
spatial transcriptomics
- From:
Journal of Modern Urology
2026;31(2):187-192
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma is one of the most common malignant tumors of the urinary system.Its pronounced heterogeneity plays a crucial role in disease progression, treatment responses, and clinical outcomes.This review focuses on the heterogeneity of the tumor microenvironment in renal cell carcinoma, summarizing the key cellular interactions, the evolution of immunosuppressive states, and the reciprocal regulation between tumor and stromal components.The paper further discusses the clinical impacts of heterogeneity on immuno-targeted combination therapy, along with the application of emerging technologies, such as single-cell sequencing and spatial transcriptomics, so as to provide theoretical insights and practical guidance for the precision therapy for renal cell carcinoma.
