Analysis of the association between weight-adjusted waist index and prostate cancer using the US NHANES database
10.12483/j.issn.1009-8291.2026.02.004
- VernacularTitle:基于美国NHANES数据库分析体质量调整腰围指数与前列腺癌的相关性
- Author:
Jianqiang YE
1
;
Lili LIN
1
;
Zewen HAN
1
;
Ang LI
1
;
Han JIANG
1
Author Information
1. PET Center, Union Hospital Affiliated to Fujian Medical University; Fujian Provincial Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors (Fujian Medical University); Fujian Provincial Clinical Research Center for Radiology and Radiotherapy, Fuzhou 350001, China
- Publication Type:Journal Article
- Keywords:
weight-adjusted waist index;
prostate cancer;
central obesity;
National Health and Nutrition Examination Survey (NHANES)
- From:
Journal of Modern Urology
2026;31(2):121-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the weight-adjusted waist index (WWI) and prostate cancer (PCa) in order to provide reference for the screening and diagnosis of PCa.Methods Data of 18732 men aged ≥20 years were obtained from the US National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2018. The relationship between WWI and PCa was assessed using a multivariate logistic regression model.A stratified analysis was performed across four time periods:1999—2006, 2007—2010, 2011—2014, and 2015—2018.Restricted cubic splines (RCS) and subgroup analyses were employed to evaluate the potential nonlinear associations and interactions between WWI and PCa risk. The receiver operating characteristic (ROC) curve was utilized to compare the predictive performance of WWI with other obesity-related indicators, including waist-to-height ratio (WtHR), body mass index (BMI), waist circumference, and body weight.Results In the fully adjusted model, each 1-unit increase in WWI was associated with a 74% higher risk of PCa (OR=1.74, 95%CI:1.44-2.11, P＜0.001).Individuals in the highest quartile of WWI had nearly five times greater odds of PCa compared to those in the lowest quartile (OR=4.96, 95%CI:2.69-9.15, P＜0.001).The observed association remained consistent across all four survey cycles.RCS analysis revealed a nonlinear positive association between WWI and PCa risk. Threshold analysis indicated that when WWI ≥9.97, there was a significant positive correlation with PCa risk (OR=1.39, 95% CI:1.18-1.64, P＜0.001).Subgroup analyses confirmed the robustness of this association across different demographic and clinical subpopulations.Furthermore, WWI demonstrated superior discriminatory ability for predicting PCa compared to WtHR, BMI, waist circumference, and body weight (AUC=0.706, 0.608, 0.509, 0.594, 0.488, P＜0.001).Conclusion For the general male population in the US, WWI serves as an independent risk factor for PCa.This association has remained stable over 1999—2018, and WWI outperforms conventional obesity indicators in terms of predictive accuracy.Therefore, individuals with WWI ≥9.97 should be prioritized for prostate-specific antigen (PSA) screening, which may enhance current screening and diagnostic strategies.
