Secondary metabolites of the endophytic fungus Alternaria alstroemeriae from Pseudostellariae Radix
10.11665/j.issn.1000-5048.2026022802
- VernacularTitle:一株太子参植物内生真菌链格孢菌次生代谢产物的研究
- Author:
Bingyun LU
1
;
Li FENG
;
Wenhui YANG
;
Yuanxiang GONG
;
Zhe WANG
;
Lijun HAO
Author Information
1. 中国药科大学理学院, 南京211198;中国药科大学中药学院, 南京211198
- Publication Type:Journal Article
- Keywords:
Pseudostellariae Radix;
endophytic fungus;
Alternaria alstroemeriae;
secondary metabolites;
isolation and identification;
antimicrobial activity
- From:
Journal of China Pharmaceutical University
2026;57(3):322-331
- CountryChina
- Language:Chinese
-
Abstract:
Sixteen compounds were isolated from the solid rice culture of the endophytic fungus Alternaria alstroemeriae WZ-419 derived from Pseudostellariae Radix, using silica gel, ODS, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were elucidated based on physicochemical properties and comprehensive spectroscopic analyses, and identified as alterpenoid A (1), tricycloalternarene A (2), altenusin (3), 4'-epialtenuene (4), altenuene (5), alternariol (6), altenuisol (7), 3-hydroxyalternariol-5-O-methylether (8), alternariol-9-methyl ether (9), alternariol 1′-hydroxy-9-methyl ether (10), stemphyperylenol (11), dihydroalterperylenol (12), alterinone A (13), 4-hydroxy-3-methoxy-5-(2E,6E-3,7,11-trimethyldodeca-2,6,10-trien-1-yl) benzoic acid (14), hexylitaconic acid (15), and altechromone A (16). Among them, compound 1 and 13 were new, and compounds 14 and 15 were isolated from the genus Alternaria for the first time. The antibacterial activities of compounds 1–16 were evaluated in vitro. Compounds 3, 6–8, 10, 11, 13, and 14 exhibited notable inhibitory effects against Gram-positive bacteria, with minimal inhibitory concentrations ranging from 8 to 64 µg/mL.This study isolated a series of antimicrobial metabolites from the endophytic fungi of Pseudostellariae Radix, providing new insights into their bioactive constituents and laying a foundation for further pharmacological investigations.
