Extraction of tetralones and quinic acids from Cyclocarya paliurus
10.11665/j.issn.1000-5048.2025112404
- VernacularTitle:青钱柳中的四氢萘酮类和奎宁酸类成分
- Author:
Yu YE
1
;
Siyang FANG
;
Xiao LI
;
Lei WANG
;
Jian ZHANG
;
Ke PAN
;
Zhiqi YIN
Author Information
1. 中国药科大学中药学院, 南京 211198;江苏省中医药研究院转化医学实验室, 南京 210028;中国药科大学药学院, 南京 211198
- Publication Type:Journal Article
- Keywords:
Cyclocarya paliurus;
tetralones;
quinic acid
- From:
Journal of China Pharmaceutical University
2026;57(3):314-321
- CountryChina
- Language:Chinese
-
Abstract:
Chemical constituents of n-butanol fraction of ethanol extract from the leaves of Cyclocarya paliurus (Batalin) Iljinskaja were studied. Ten compounds were purified by silica gel, MCI, ODS, Sephadex LH-20 column chromatography and semi-preparative high-performance liquid chromatography. Based on the physicochemical properties and spectroscopic data, these compounds were identified as (4S)-4,8-dihydroxy-α-tetralone-5-[6′-(3′′,5′′-dimethoxy-(E)-p-coumaroyl)]-β-D-glucopyranoside (1), (4S)-4,8-dihydroxy-α-tetralone-5-[6′-(E)-feruloyl]-β-D-glucopyranoside (2), (1S,3R,4S,5R)-4,5-di-O-caffeoyl quinic acid methyl ester (3), (1R,3R,4S,5R)-3,4-di-O-caffeoyl quinic acid methyl ester (4), (3R,5R)-3,4,5-tri-O-caffeoylquinic acid methyl ester (5), (1R,3R,4S,5R)-3-O-caffeoyl-5-O-p-coumaroyl quinic acid methyl ester (6), (1R,3R,4S,5R)-3-O-p-coumaroy-4-O-caffeoyl quinic acid methyl ester (7), (1R,3R,4S,5R)-3-O-caffeoyl-4-O-p-coumaroy quinic acid methyl ester (8), (3R,5R)-3,5-di-O-caffeoyl quinic acid methyl ester (9) and (1S,3R,4R,5R)-4-O-caffeoyl-5-O-feruloyl quinic acid methyl ester (10). Among them, compound 1 was a new compound, and compounds 3–10 were isolated from the genus Cyclocarya for the first time.
