Study on synthetic process of 18α-glycyrrhizic acid
10.11665/j.issn.1000-5048.2025081501
- VernacularTitle:18α-甘草酸的合成工艺研究
- Author:
Yuxing LI
1
;
Xueyan MA
;
Ke ZHAO
;
Jiaxing ZHAO
Author Information
1. 兰州交通大学生物与制药工程学院, 兰州730070
- Publication Type:Journal Article
- Keywords:
18α-glycyrrhizic acid;
synthesis;
process optimization
- From:
Journal of China Pharmaceutical University
2026;57(3):288-294
- CountryChina
- Language:Chinese
-
Abstract:
In this study, the synthetic process of 18α-glycyrrhizic acid was optimized. Using 18β-glycyrrhizic acid monoammonium salt as the starting material, the target compound 18α-glycyrrhizic acid was obtained through isomerization, esterification, and hydrolysis, with a total yield of 9.43%, purity of 99.23% and key impurity A of 0.17% (HPLC). The optimized process significantly improved the isomerization conversion rate, reduced the formation of related substances, simplified the purification steps, and enhanced both industrial scalability and cost efficiency.
