Association between brain and muscle Arnt like protein 1 gene polymorphisms and ambulatory blood pressure among college students
10.16835/j.cnki.1000-9817.2026183
- VernacularTitle:脑和肌肉芳香烃受体核转运样蛋白1基因多态性与大学生动态血压的关联
- Author:
ZENG Yuan, MAO Bin, ZHANG Jixin, ZHANG Jian, LI Shang,〖JZ〗 WU Zhe, ZHANG Yuhao, XIA Sha,YANG Xuanhao, ZHENG Chanjuan, YANG Yide
1
Author Information
1. Department of Schistosomiasis, Endemic and Parasitic Diseases Prevention and Control, Changsha Municipal Center 〖JZ〗for Disease Control and Prevention (Changsha Bureau of Comprehensive Health Inspection and Law Enforcement), Changsha 410003, Hunan Province, China
- Publication Type:Journal Article
- Keywords:
Genes;
Blood pressure;
Regression analysis;
Students
- From:
Chinese Journal of School Health
2026;47(6):864-868
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between brain and muscle Arnt like protein 1( BMAL 1) gene and ambulatory blood pressure (ABP) parameters in college students, and to explore the influence of the interaction between the gene and weight status on the ABP levels, so as to provide reference for early prevention of chronic cardiovascular diseases related to hypertension.
Methods:During September 2022 to June 2024, a total of 510 college students were recruited from a university in Changsha, China for on site questionnaire investigation, physical examination, ABP monitoring and genotyping testing. Multiple linear regression method was used to explore the association between the BMAL 1 gene and ABP indicators. An interaction term was included in the general linear model of multiple linear regression to analyze the interactive effects of BMAL 1 gene polymorphisms and weight status on ABP levels.
Results:The prevalence of abnormal 24 hour blood pressure, abnormal daytime blood pressure, and abnormal nighttime blood pressure were 3.3%, 3.1%, and 3.9%, respectively. Multiple linear regression analysis showed that the BMAL 1/rs7950226 polymorphism was positively correlated with the 24 hour diastolic blood pressure(DBP) and the daytime DBP level after adjusting for gender, age, and body mass index( β =0.87,0.99, both P <0.05). Also, interaction between BMAL 1/ rs 11022775 and weight status on the nighttime DBP level ( P interaction =0.03) was found. The CC genotype carriers had significantly higher nighttime DBP level ( β =3.52, P <0.05) among overweight/obesity college students, but no differences in nocturnal DBP levels were observed between CC genotype carriers and TT+CT genotype carriers among college students with normal body weight( P > 0.05).
Conclusions:The rs 7950226 polymorphism is associated with 24 hours DBP and daytime DBP levels. Significant interaction between rs 11022775 with weight status on the nighttime DBP level is found among college students.
