Research progress of macrophage-related microRNA in rheumatoid arthritis
10.19405/j.cnki.issn1000–1492.2026.05 022
- VernacularTitle:类风湿关节炎中巨噬细胞相关微小核糖核酸的研究进展
- Author:
Qijiang JIANG
1
;
Chenggen LUO
2
;
Yanjuan CHEN
3
;
Mei TIAN
1
;
Yong CHEN
1
Author Information
1. Department of Rheumatology and Immunology， Affiliated Hospital of Zunyi Medical University， Zunyi 563000
2. Department of Nephrology， Tongren People's Hospital， Tongren 554300
3. Guizhou Key Laboratory of Cell Engineering， Affiliated Hospital of Zunyi Medical University， Zunyi 563000
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
microRNA;
macrophage polarization;
inflammatory response;
signaling pathways
- From:
Acta Universitatis Medicinalis Anhui
2026;61(5):955-960
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis （RA） is an autoimmune disease characterized by chronic synovial inflammation and joint destruction， with a complex pathogenesis. Macrophage polarization plays a pivotal role in disease progression. Recent studies demonstrate that microRNA （miRNA）， as critical post-transcriptional regulators， can participate in the inflammatory response process by regulating the polarization state of macrophages， thereby aggravating RA joint damage. This review summarizes the mechanism of action of various miRNA in regulating macrophage polarization， and emphasizes their potential therapeutic value in RA.
