Relationship between EDNRA gene polymorphisms and congenital bilateral absence of the vas deferens in the male Han Chinese population
10.19405/j.cnki.issn1000–1492.2026.05 018
- VernacularTitle:EDNRA基因多态性与汉族男性先天性双侧输精管缺如的相关性研究
- Author:
Yuwan PENG
1
;
Xiaojin HE
2
;
Xiaoyu YANG
3
;
Jing WANG
4
;
Binbin WANG
4
;
Dongdong TANG
5
;
Zhaolian WEI
5
;
Yunxia CAO
5
Author Information
1. Department of Obstetrics and Gynecology
2. Reproductive Medicine Center， Shanghai First People's Hospital， Shanghai 200080
3. Reproductive Medicine Center， Jiangsu Province Hospital， Nanjing 210009
4. National Research Institute for Family Planning， Beijing 100081
5. Reproductive Medicine Center ，The First Affiliated Hospital of Anhui Medical University， Hefei 230022
- Publication Type:Journal Article
- Keywords:
progestin-primed ovarian stimulation protocol;
luteal phase long protocol;
antagonist Protocol;
embryo euploidy rate;
frozen-thawing embryo transfer
- From:
Acta Universitatis Medicinalis Anhui
2026;61(5):931-936
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association between endothelin receptor type A gene （EDNRA） and congenital bilateral absence of the vas deferens （CBAVD）. MethodsThis case-control study consisted of 124 subjects with CBAVD and 100 fertile controls.Two single nucleotide polymorphisms （SNPs： rs5335 and rs1801708） in the EDNRA gene were genotyped via PCR， PCR-RFLP analysis， and direct sequencing. ResultsNo significant differences existed between EDNRA polymorphisms and CBAVD phenotype （rs1801708： P=0.220 2， 0.163 2； rs5335： P=0.805 8， 0.818 6）. However， the rs1801708-rs5335 haplotype AG was notably associated with an increased risk of CBAVD （P=0.008 6， OR=2.178， 95% CI： 1.207-3.929）. A significantly protective effect of rs1801708-rs5335 haplotype GG on CBAVD （P=0.038 5， OR= 0.671， 95% CI： 0.460-0.980） was observed. After Bonferroni correction， the result for haplotype A-G remained significant （P =0.008 6<0.012 5）， while haplotype G-G was not significant. ConclusionThe rs1801708-rs5335 AG haplotype of EDNRA is a potential risk factor for CBAVD development in Han Chinese.
